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Summary
Nuclear receptors constitute a superfamily of ligand-dependent transcription factors, which include receptors for steroid hormones, retinoids, thyroid hormone and eicosanoid metabolites, and orphan receptors. These receptors play critical roles in the regulation of embryonic development and of many physiological processes in the adult (see figure 1).
In addition, data have implicated nuclear receptors in a number of diseases, including inflammation, osteoporosis, and metabolic syndrome. Researchers use synthetic antagonists for several nuclear receptors to effectively treat asthma, diabetes, atherosclerosis and cancer. Chemicals in the environment can influence receptor signaling pathways directly by functioning as agonists or antagonists of receptors. This interaction may lead to untimely activation of receptors or disruption of receptor signaling. Inversely, nuclear receptors regulate the metabolism of xenobiotics and drugs (see figure 1).
Copyright status
This image is public domain because it was first published by the National Institutes of Health
Source
http://www.niehs.nih.gov/research/atniehs/labs/lrb/cell-bio/retinoid.cfm
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| Date/Time | Thumbnail | Dimensions | User | Comment |
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| current | 05:01, 5 August 2008 |  | 450 × 464 (42 KB) | Ashcraft | |
| 05:00, 5 August 2008 |  | 450 × 505 (33 KB) | Ashcraft | Nuclear receptors constitute a superfamily of ligand-dependent transcription factors, which include receptors for steroid hormones, retinoids, thyroid hormone and eicosanoid metabolites, and orphan receptors. These receptors play critical roles in the reg |
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